We do not endorse non-Cleveland Clinic products or services. The commonly available sources of hyaluronic acid, besides its natural . 2021;17(7):823-840. doi:10.1080/17425255.2021.1931682, Colletti A, Cicero AFG. A pilot study. Targeted clindamycin delivery to pilosebaceous units by chitosan or hyaluronic acid nanoparticles for improved topical treatment of acne vulgaris. 2020;11(1):53-69. doi:10.1007/s13555-020-00468-7, Desmawati D, Sulastri D. A phytoestrogens and their health effect. Product classification. The 20 MDa HA found in cellulite / water retention is actually produced by the body itself, without any external help, due to uncontrolled inflammation in those tissues. Hyaluronic acid has beneficial properties when used on your skin. This differential absorption capability of HA depending on its molecular weight is the reason why more and more cosmetic companies these days use more than one size of HA. Hyaluronic acid sizes are divided in different categories: Oligomeric HA / HA oligomers: anything from 800Da - 10kDa. In addition, it leaves the skin supple and soft. 2015;15(1). Although not all of these side effects may occur, if they do occur they may need . This is, however, a very naive thought, based on several misunderstandings: Supplements contain the proper hyaluronic acid, i.e. Interactions between HA and these prescription drugs are unclear. Does hyaluronic acid have an anti-aging effect? Sometimes doctors inject hyaluronidase into tissues to break down the excessively high molecular weight HA (>> 2 MDa), that we mentioned above in reference to cellulite. What Happens If I Take Too Much Hyaluronic Acid ? The number of repeat disaccharides in a completed hyaluronan molecule can reach up to up to 20,000,000 Dalton in vivo. Hyaluronic acid supplements taken by mouth are also considered safe (but you should still tell your healthcare provider about them, as you would for any other medication, vitamin or supplement). Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. Monfort J, Rots-Sala D, Segals N, et al. Store HA supplement in a cool, dry place and keep HA away from direct sunlight. (https://pubmed.ncbi.nlm.nih.gov/31715233/), Visitation, mask requirements and COVID-19 information. 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event. Hyaluronic acid, also called hyaluronan, is naturally produced by the human body and is an essential component in skin hydration. 1. "Hyaluronic acid contains no calories, so it cannot directly lead to weight gain either. While HA as a dietary supplement exhibits no side effects, potential side effects may occur depending on the application method, such as an injection into the joint or topical application. (1), However, it has never been reported to cause weight gain. Trademarks: Meso-CRF, LipoTherapeia and Celluenceare registered trademarks in the UK & EU and belong to LipoTherapeia Ltd. All rights to the usage of those trademarks and copyrights are strictly reserved and are only allowed with prior written approval. (3). UV radiation from the sun tends to diminish hyaluronic acid, leading to skin dryness and inflammation. Topical application of creams, gels, and lotions containing phytoestrogens (plant-based estrogens) for 12 to 24 weeks has increased hyaluronic acid levels. On the other hand, anything above 1,000 kDa (1MDa) stays on the surface of the epidermis, with the skins native 2,000 kDa (2MDa) hyaluronan being totally unable to penetrate the epidermis. This is because the molecule is simply too large to squeeze between the gaps in our skin. Current Medical Research and Opinion. doi:10.1186/s12937-016-0130-8, Singhal S, Hasan N, Nirmal K, et al. J Appl Oral Sci. https://pubmed.ncbi.nlm.nih.gov/27012203/. 2021;18(5):2383. doi:10.3390/ijerph18052383, Chmielecka-Rutkowska J, Tomasik B, Pietruszewska W. The role of oral formulation of hyaluronic acid and chondroitin sulphate for the treatment of the patients with laryngopharyngeal reflux. Hyaluronic acid was originally derived from rooster comb. 2010;29(5):535-539. doi:10.1007/s10067-010-1372-z, Yang JJ, Zhang XM. Anti-obesity potential of enzymatic fragments of hyaluronan on high-fat diet-induced obesity in C57BL/6 mice. For example, since HMWHA decreases inflammation and may weaken the immune system, intra-articular (within the joint) injection of HMWHA is used to treat osteoarthritis. However before discussing how hyaluronic acid works and what it can do for your skin, it would be good idea to first present an 101 on hyaluronic acid, so that we can better understand its mode of action. Thank you, {{form.email}}, for signing up. This is because about 90% of it is metabolized and eliminated via expiration and urine. In a double-blind, randomized, placebo-controlled study of 60 Japanese people aged 22 to 59 who had crow's feet wrinkles (wrinkles near the corner of the eyes), taking 120 milligrams (mg) of HA in capsule form by mouth per day for 12 weeks decreased skin wrinkles. Prices and special offers: Subject to change without prior notice. Wang SJ, Wang YH, Huang LC. Thats why a quarter-teaspoon of hyaluronic acid can hold about one and a half gallons of water, making it the best polymer natural or artificial for absorbing water (and a key ingredient in moisturizing products). doi:10.1186/s12937-016-0128-2, Simental-Menda M, Snchez-Garca A, Vilchez-Cavazos F, Acosta-Olivo CA, Pea-Martnez VM, Simental-Menda LE. As we age we produce less and less HA and we are in need of protecting and boosting the levels of HA in our skin. As we mentioned above, we must really know what we are doing with lower molecular weight HA, so shoving a 20 kDa HA into the skin is not the solution to everything, as this may prove either beneficial or irritating. ", Note: this is some food for thought for those ignorant experts in the media who claim that active ingredients do not penetrate the epidermis to reach the dermis for therapeutic purposes. Linear is the standard HA found in the body and in nature. Does hyaluronic acid have an anti-aging effect? On skin hyaluronic acid is found mainly on the base of the epidermis (skins uppermost layer), maintaining the space between cells, hydrating the skin and facilitating the passage of nutrients there. Along with its needed effects, a medicine may cause some unwanted effects. Nutrition Journal. 2020;72(3):125-130. doi:10.4081/reumatismo.2020.1272, Litwiniuk M, Krejner A, Speyrer MS, Gauto AR, Grzela T. Hyaluronic acid in inflammation and tissue regeneration. Top 5 Reasons to Try Hyaluronic Acid For Vaginal Dryness. Hyaluronic acid: molecular mechanisms and therapeutic trajectory, Menopause and the skin: old favorites and new innovations in cosmeceuticals for estrogen-deficient skin, Fruits (apples, pomegranates, and chaste berries), Intra-articular (within the joint) injection. Hyaluronic acid is naturally produced by the body and is used in. Other benefits of HA include alleviating acid reflux symptoms and promoting wound healing. Some factors that reduce the amount of HA in the body include aging, solar ultraviolet radiation, smoking, and air pollutants. Pediatric Pulmonology. Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid features and clinical indices in knee osteoarthritis. Clinical Colorectal Cancer. In the video, she spoke about naked mole rats, their longevity, and their high-molecular-weight . Kristina Liu MD, Janelle Nassim MD. Is vaginal hyaluronic acid as effective as vaginal estriol for vaginal dryness relief? The average molecular weight of hyaluronic acid is 4 MDa in joints and about 2 MDa in skin. For information purposes only: All content on this website is strictly for information purposes only. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation, mask requirements and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. Peanut butter is also a good source of monounsaturated fat and antioxidants as well as vitamins and minerals that will help your body stay healthy and function properly. Eye health, especially for treating dry eyes. Home > Nutrition > Does Hyaluronic Acid Cause Weight Gain? No, hyaluronic acid does not cause chronic water retention. Wounds. A low molecular weight HA with 1% water would be a much thinner liquid or very thin gel, while an oligomer with 1% water would be as runny as water. HA in its natural form is also known as high molecular weight hyaluronic acid (HMWHA). Hyaluronic acid can help people with dry skin to retain moisture and hydration and improve their quality of life. The difference in the molecular weight of HA can mean different effects. Nonetheless, conflicting results regarding the serious side effects of HA injections have also been reported. not too many oligomers or even 200DA-10kDa HA, as these are known to stimulate inflammation. The larger 3-20MDa HA, i.e. HA has the incredible capacity to attract and hold onto 1000x its weight in moisture. Special offers can not be combined. https://pubmed.ncbi.nlm.nih.gov/25439759/. Hyaluronic acid can increase eye pressure when injected into the eye. So 20+ years on, we still keep it real, regardless of AI. 10 11. Not surprisingly this quite often results in permanent damage (the latest such fad is microneedling radiofrequency). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376784/. Our expert physicians and surgeons provide a full range of dermatologic, reconstructive and aesthetic treatments options at Cleveland Clinic. Your body has about 15 grams of hyaluronic acid, and about 1/3 (one-third) of it is degraded ever day. A pilot study, Hyaluronic acid in inflammation and tissue regeneration, Human skin penetration of hyaluronic acid of different molecular weights as probed by Raman spectroscopy. Hyaluronan can also be taken orally, in the form of a nutritional supplement, and it actually does reach skin and joints and does help with hydration/anti-ageing and with joint health, respectively. However, the study was limited because it did not have a placebo group. Eur Rev Med Pharmacol Sci. Combine peoples ignorance, extreme marketing hype and greedy skincare companies and what do you get? Replenishing the skin with hyaluronic acid is effective in combating the natural aging process. Injectable hyaluronic acid is only used in people who don't get enough relief from other treatment options for OA of the knee. 2019;6. doi:10.3389/fvets.2019.00192, Lephart ED, Naftolin F. Menopause and the skin: old favorites and new innovations in cosmeceuticals for estrogen-deficient skin. Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. This website is human-written 100%. Abstract: Background: Topical delivery of molecules into the human skin is one of the main issues in dermatology and cosmetology. In cellulite, that type of hyaluronan is what maintains the water retention in the interstitial spaces, creates the puffy, congested appearance and eventually leads to fibrosis (fibrosis is built on a hyaluronic acid scaffolding). Published February 2017. International Journal of Molecular Sciences. Please review this supplement label with your healthcare provider to discuss potential interactions with foods, other supplements, and medications. (8). Top 10 Benefits of Alpha-Lipoic Acid Encourages normal thyroid hormone levels Supports healthy nerves Promotes normal heart health Protects muscles from exercise-related stress Supports the liver Promotes a strong brain and sharp memory Encourages healthy skin Promotes graceful aging Maintains healthy blood glucose levels Low molecular weight hyaluronic acid can cause inflammation, so it is vital that high molecular weight is the one you consume." The DoNotAge page contains a link to a video of Prof. Gorbunova, an author of one of the papers cited by selenic above. All other molecular weights (50 kDa-2 MDa) seem to be neutral or beneficial, with 2MDa being considered to be the most normal (if such a thing exists) and to inhibit inflammation. Published April 2015. Products that combine hyaluronic acid with other medications or compounds may have some risks of side effects. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289781/. Step 2: Once the ingredients are completely dissolved, add glycerin and chilled rose water. February 6, 2023 - Updated on March 6, 2023, Most-Asked Questions About Hyaluronic Acid and Weight Gain. Open Access Maced J Med Sci. This abnormally large size of HA is what retains water in hypodermal tissues and contributes to the appearance of cellulite and overall tissue puffiness on the calves and thighs. Safety of a single intra-articular injection of LBSA0103 hyaluronic acid in patients with osteoarthritis of the knee: a multicenter, single-arm, prospective, cohort study. Due to such risk factors, HA supplementation has gained popularity in the health, food, and cosmetic industries. Non-medical: No information, treatment or product on this website aims to treat or diagnose any medical condition or to provide/replace medical advice. 4 MDa in joints and about 1/3 ( one-third ) of it is degraded day. When injected into the eye have some risks of side effects may occur if... 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