I hate to use anything, but also tired of keeping my dogs in a bubble. Luckily, Simparica Trio for dogs is considered fairly safe. , Thanks for the reply! Ill list all the options I looked into (including several Ive personally tried), along with whether theyre considered safe to use, use with caution, or a complete no-no. The more common complaint with Frontline Plus is that its not strong ENOUGH for a lot of people, since it lacks repellent properties. Honestly, I think K9 Advantix would beat Credelio as far as effectiveness, due to its repellent properties and ability to kill on contact. . The Wondercide website says, We recommend testing any new product you introduce to your pet or environment eight hours prior to a full application to ensure there are no sensitivities. With cedar oil being the main ingredient, it should be relatively safe; but its best to be cautious, especially as your girl has proven to be so sensitive. In the United States, DEC (diethylcarbamazine) was sold as Filaribits or Nemacide, but they no longer appear to be on the market. Dogs with the mutation will react to those drugs. If you live in an area where the fleas just refuse to die, you may want to consider an alternative, stronger product. ? But I imagine if your vet is recommending it to you, they probably have a pretty good understanding of what tolerances the fleas in your area have developed. As with everything else, monitor your dog for symptoms. Miscellaneous Seresto was his answer, so I asked how effective it would be on a double-coated breed. I didnt see the link for the drug compatibility. However, a dog with . Thank you! (The Environmental Protection Agency is responsible for approving external flea and tick products.) Selamectin is their shared main ingredient. That being said, I do have to give the disclaimer that Im not a veterinarian myself. mg) Indications On the down side, it does not cover any ticks. However, I have to state the disclaimer that even parasite protection products officially labeled safe from an MDR1 standpoint should really be designated safe-ish. Most of these products are chemical compounds, and as such have more potential to cause a reaction than just, well, water. Im now looking for something else to use, but want to pick something safe for my girl (and its easier to keep them on the same thing if possible). According to Dr. Jean Dodds of Hemopet, researchers and veterinarians thus far cannot point to breed characteristics, age group, drug interactions or genetic mutations as contributing factors to the latest findings that prompted the FDA warning. In other words, the reported adverse reactions to Bravecto had nothing to do with whether or not a dog had MDR1. Wondercide sounds like an excellent place to start as far as flea and tick prevention, and I hope it will be effective against mosquitoes, too. Im trying to find out if this is safe for her. Hello! In summary, use with caution. Another danger often lies in a treated dog being exposed to additional environmental pesticides, which can lead to an accidental overdose. Emma. I say this as she is running around the room l barking and trying to dig up the coachyep, just about nap time, That is excellent news, and Im so glad to hear it! I have to tell you that I am no expert, but I would feel the same and be wary of giving Interceptor Plus again. Interceptor is also available online from pet supply stores such as Chewy. Of all the products you mentioned, I would prefer to try K 9 Advantix since it both repels and kills. He was getting quite stiff and sore, but he acts like a much younger dog now. I was leaning towards, but have not tried, the combination of Interceptor tablets (heartworm) + Credilio (flea and tick) tablets. Other medications that should be used with caution and at reduced doses include sedatives like acepromazine and butorphanol, anti-cancer medications and more. So it really depends on the individual dogs, and you know your dogs best! Fluralaner is a novel systemic ectoparasiticide for dogs providing long-acting flea- and tick-control after a single oral dose. Additionally, it can also be given to cats and even pregnant or nursing animals. We have always used Frontline Plus, but it has recently started causing dandruff on our dog, and it makes his coat greasy. I asked the vet for an alternative and was recommended Seresto collar or Vectra 3D. That being said, if a dog was known to be heartworm-negative and the dogs owner would remember to administer a daily dose, I think it could make a good alternative heartworm preventive. But it doesnt hurt mammals. We are waiting for the results from her test for the MDR1 gene. This sensitivity is called flea allergy dermatitis. The department considered public complaints, veterinarians' reports, peer-reviewed scientific articles, and mandatory reports from the drug companies in its decision to issue the warning. Hi. Bottom line is that Simparica will probably be fine for your dog, but there is a slight risk that it wont. Based on my findings, Im not convinced of its superior safety. We often go on walks in the woods. It is safe for use with anthelmintics like heartworm meds and has no known negative drug-drug interactions. You can also reach me through the contact form here on the website. Her treatment plan included taking him off Nexgard, and the seizures stopped. Share the results with your veterinarian to let them know to avoid or adjust the dose of certain medications. Another thing to research and to ask your personal vet about might be potential drug/drug interactions between the Trazadone and Effifax, or whichever parasite preventives you choose to use in the future. (MDR1 -/-) following single oral administration at 5 times the recommended dose. On September 20, 2018, the U.S. Food and Drug Administration (FDA) warned animal caregivers and veterinarians about the risk of serious neurologic events, including seizures, muscle tremors and ataxia, in dogs and cats treated with certain flea and tick medications. (No judgment if you didnt see that section: I know its a very long article and I expect most people are looking for a quick or specific answer and dont actually read the whole thing ?.) After Simparica is given its activity against ticks and fleas lasts for at least 5 weeks. Dinotefuran in particular is a strong pesticide, and all 3 of those ingredients combined are harsh on sensitive skin. Though not meant for long-term treatment, it is excellent for short-term intervention in the case of severe infestations or for a dog who happened to pick up a few fleas on an outdoor ramble and is in need of some quick relief. Additionally, it can be used to treat and control sarcoptic mange. We will get her in about 3 weeks. The majority of canines will be fine, but there are enough who will react. (MDR1 -/-) following single oral administration at 5 times the . After 24 hours, it is considered waterproof and a bath, while alleviating some effects, will not offer as much relief. (Same active ingredients in both.) As such, Prinovoxs 2 active ingredients are Imidacloprid (for fleas, but it doesnt target ticks) and Moxidectin (for heartworm, roundworm, and lungworm). To help with this, the product can be applied in more than one line between the neck and shoulder blades. And safe travels to you and Lola in the future. In general dogs tolerate very well sarolaner at the therapeutic dose range (2 to 4 mg/kg). Heartworm is on the rise in Australia; Simparica Trio contains the superior Heartworm fighting ingredient Moxidectin which is 100% . I read that you you used this combination with success. For instance, dogs without any drug sensitivities, can take doses of ivermectin as high as 400 g/kg safely; whereas, in a dog with the MDR1 mutation, a dose as low as 50 to 100 g/kg is toxic. Personally I use Frontline Plus and supplement weekly with a Natural Chemistry spray as a repellent, but I understand that might not be ideal for everyone depending on their situations. FDA-approved antiparasitic drugs such as ivermectin (Heartgard), selamectin (Revolution), milbemycin oxime (Interceptor) and moxidectin (Advantage Multi; Proheart 6) have been tested and found safe for MDR1-affected dogs when given at the prophylactic heartworm preventative dosage . Either way, I certainly dont want to risk it for him again. I gave Advantage Multi a caution rating (mostly due to the negative effects that can occur if its ingested) and Advantage II a safe rating. However, in such sensitive breeds (which may include, but not necessarily limited to, Collies and related breeds), the recommended dose should be strictly observed. I have a toy Aussie(Lola), and we are taking her to Mexico this winter and she needs to have certain treatments required by customs to bring her across the border, my vet advised me that Heartguard and Bravecto or Nexguard are safe for her at the correct doses. I had never heard of Dimmitrol before, but I did some research after reading your comment. The most common side effect of Simparica is vomiting, which can happen within the first hour or two after administration. I myself have successfully used both on my 2 Collies and my Aussie mix with no ill effects. I hope you get this. I live on a farm that borders a forest, so coyotes/deer etc.. no avoiding ticks. Leaders in MDR1 testing since 2004. 2022 Collie Chatter. We have an MDR1 heterozygous Aussie and this was the best breakdown of the meds we found. But the drug works just like Bravecto and Nexgard it destroys flea and tick nervous systems. The product insert states Do not use this product on debilitated, aged, medicated, pregnant or nursing dogs, or dogs known to be sensitive to pesticide products., If you live in a seasonal region where you actually experience winter complete with freezing temperatures and snow, and your pets have been on regular pest preventive products, you can give them a break from chemicals for a few months while the insects are dormant. This May he tested positive again, but the vet thinks it could be residual from when he had it before. Bear in mind that my opinion is by no means professional, but personally Id go with your first vets prescription. In regard to natural products, Ive used some organic topicals, which Ill list later, that aresomewhat effective as repellents; but unfortunately I do not know of any natural pest control products that actually work as well as chemical-based ones. So heres the culmination of my research: information gathered from laboratory case studies, veterinarians, and Collie owners, breeders, and exhibitors. Frontline Gold and Frontline Shield. We do eat it! Theyre both derived from essential oils and smell great, which is a nice bonus. If your dogs arent reacting to it, why are you switching? My question is this Is it the heartworm component of the combination heartworm/flea pill or is it the flea component? Anecdotally anyway, it is reported to have gentler ingredients and the least tendency to cause skin irritations. Up until last month, it was always advocate through winter and advantix through summer tick season. Turns out it is also used for the treatment and prevention of roundworms and lungworm nemotodes in dogs, according to Vet Shop Max. A product this strong may not be best for a dog that has sensitive skin issues, as irritation can develop at the site of application. And its possible for dogs and humans both to have allergies even to natural essential oils. The collar releases no odor or residue, comes with a quick release catch to prevent accidental choking, and even has safety reflectors. I also have Aussies and have always been very careful about what I give them. This gave me a great start for research. Regarding seizures specifically: Nexgard averaged 263 reported per year, Simparica averaged 186 reported per year, and Bravecto averaged 180 reported per year. I have an Aussie mix and desperately needed some info on this. I have two Miniature Australian Shepherds that are my entire world: Nola Riley and Otis Kai : ) Nola is MDR1-Heterozygous. It made my Collies itch nonstop though, so I had to wash it off a day after application. The amped-up version, Interceptor Plus, also contains praziquantel, which is used to treat tapeworms. Id like to have a Border Collie one day, but as I have some health issues Im not sure I could keep up with one. Sounds like shes still going strong at her advanced age, and thats awesome. ? Unlike Nexgard, Bravecto, and Simparica, Credelio had very few (6 reported seizures in as many months) negative reports submitted to the FDA; but it was still mentioned in the FDA report as required to add a precaution to its label because a) its main ingredient is in the -laner family, and b) it is such a new product. (I have to give them baths with a very mild or medicated shampoo.) I interviewed a few people (rescue workers, owners, and breeders) from that group for this article I wrote about Border Collies. The FDA thinks this drug is safe to use on your dog. First, I want to thank you for the time and effort that went into writing this article. The following list shows the common dog breeds most likely to have the MDR1 mutation, and the percentage affected in each. And thank you for saying so. (I googled veterinary pharmacists near me and found one locally, but Jacksonville is a huge city.) for dogs 1.3-2.5 kg 5 for dogs >2.5-5 kg 10 for dogs >5-10 kg 20 . Hi Emily, this is a great article and I appreciate all of your research! Your thoughts? I found some good information on the Cyphenothrin in Parastar Plus in this article. Please let me know how the Wondercide works for you! Ive had success using Burts Bees ear rinse on my dogs. Another safe heartworm medication is the daily dimmitrol. , I use Advecta 3 because it prevents and kills I have been in the dog Bussiness for over 26 years and used to use frontline bit past few years switched because frontline doesnt prevent .I never had a problem with advecta 3 and hope its safe, As this is a Collie blog and I assume the majority of people who read this post have a Collie, Im just hesitant to recommend it since many Collies have issues with sensitive skin even if theyre clear of MDR1. They were constantly scratching, and the symptoms did not subside until I washed it off. Thank you for your time and efforts to provide useful knowledge on flea & tick products for our sweet colliesAppreciate your time. It was both well written, and concise. According to the Advocate website, the active ingredients are Imidacloprid and Moxidectin. In my opinion, this spray is great combined with anything since it has repellent properties and smells delightful. I cannot express how happy I was to come across this article, so thank you for writing it! Specifically, does it contain any form of -mectin (i.e. Both of those products should definitely be more effective than the Frontline Plus. Hi! ( I had to get a different vet for my pup because my current vet couldnt get him in to start his vacines for 2.5 months. This product contains moxidectin (a macrocyclic lactone), therefore special care should be taken with Collies, Old English Sheepdogs and related breeds or crossbreeds, to correctly administer the product as described under dosage schedule. Best of luck with your new girl! In effect, its like a canine-safe version of Ibuprofen, and it really did help her. What an awesome article. Their treatment for this was nexgard and medicated baths. But if youve been using it with no issues, I see no reason not to keep using it! Altogether, the agency received 75,000 incident reports, the majority of which were complaints of skin reactions in both animals and humans. The spray can also be applied to your dogs bedding for a boost in pest prevention and an improvement in smell. (Most vets are going to recommend to you the products they carry in stock, but you can order online from Chewy or pet pharmacies.) For dogs that do experience side effects, the most common symptoms are vomiting and diarrhea. My dog was under the 6 month mark that most dogs start idiopathic epilepsy, he could not have had a history. Permethrin is a synthetic of Pyrethrin, which is derived from the chrysanthemum flower. Hope this helps! Hes just a puppy himself and was already started on Interceptor and Credelio. Revolution and Stronghold even tested safe over the recommended monthly dosage for dogs with the MDR1 gene, and they hold the distinction of being the only heartworm meds that did not produce any negative drug reactions. He likely does not even have a seizure disorder- just a reaction to this de-wormer that I was assured over and over again was a great thing for . Flea allergy dermatitis tends to occur mostly in the late summer. Though all of these medicines had previously been approved by FDA scientists, now data received by the agency indicates that some animals receiving Bravecto, Nexgard, or Simparica have experienced adverse events such as muscle tremors, ataxia, and seizures.. Sarolaner is also used in combination products for both dogs and cats. Of course, I do have to state the disclaimer that theres no guarantee with any product that it wont cause a reaction, but it sounds like youre doing a good job of monitoring your girl after giving her anything. Thank you. Happy to be of help! Based on its limited coverage of external parasites, cautionary potential side effects label, and its non-endorsement for pregnant or nursing females, I decided I could do better for my dogs. Ive already modified this article a few times since I originally published it, and Im definitely keeping my eye on Credelio to see what else will come out about clinical trials or reported side effects. We actually live in New Hampshire and hike (off-leash) quite frequently. Happy to help! No toxicity was seen when affected dogs were given 28 to 35.5 mcg/kg monthly for one year. Before I got them home, they went into comas. The manufacturer of ProHeart has tested the product for safety in dogs with the MDR1 mutation. Just checking in to see how you and your pup are doing and if you ended up using Seresto collars or not. His food hadnt changed, so Im nearly certain it was an adverse reaction to the Credelio. At high doses, however, such as those used in treating parasites such as demodectic mange, ivermectin can cause neurologic effects in dogs with the MDR1 mutation. Thank you for the useful information which is a little easier (clearer) to understand than most. The drug must be given daily and if more than two days are missed the risk of heartworm infection is significant.. This organic powder is great for a variety of uses. I doubt these would be cheaper than fipronil but it's worth checking. No adverse effects were observed. Based on your recommendations, I will not use Vectra. We took her to a vet who is very experienced with collies (she helps with a rescue) and has assured me that Simpirica Trio is safe. My personal quest to find the safest parasite protection for dogs known to carry the MDR1 (Multi Drug Resistance) gene led me on a merry chase. Have you had any issues with Seresto? Thank you so much for writing this article!!! In September of 2018, the FDA issued a warning to all users of Bravecto (fluralaner), Nexgard (afoxalaner), and Simparica (sarolaner). March 2016 saw the addition of Simparica, yet another so-called Isoxazoline flea and tick "remedy" and already several dogs have been adversely affected by this new drug. As a drug in the isoxazoline class, all Simparica products should be used with caution in dogs with a history of seizures, epilepsy, or neurologic disorders. You should still keep an eye on your pet when introducing new organic products. There are other risks involving Ivermectin. It seems unlikely for that much time to elapse before a reaction, but I would definitely consult with a veterinarian. Before being approved by the FDA and released to the public, clinical trials were performed on Beagles (who are prone to seizures) and Collies (who are prone to MDR1). Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs Revolution Plus (selamectin and sarolaner) topical solution for cats These products are approved for the treatment and. This product should only be used in dogs and puppies over 8 weeks and who weigh more than 2.8 pounds. I will try to find the article again, I stupidly didnt bookmark it. What do you know about this? Giardia can be passed to and cause diarrhea in humans. Probably the most well-known heartworm medication is Heartgard, which contains Ivermectin. for, I think its brown ticks. However, heartworm preventatives are still safe for MDR1 drug-sensitive dogs to take at low, FDA-approved dosages. 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